Subject
Case control study, Guillain-Barré syndrome, New Caledonia, Zika virus, [SDV]Life Sciences [q-bio], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology

Domains
Santé, Biologie, Sciences du vivant

Description

International audience Zika virus (ZIKV) infection has been associated with neurologic disorders including Guillain-Barré syndrome (GBS). In New Caledonia during the ZIKV outbreak (2014-2015), case-control and retrospective studies have been performed to assess the link between ZIKV and GBS. Among the 15 cases included, 33% had evidence of a recent ZIKV infection compared to only 3.3% in the 30 controls involved. All patients were Melanesian, had facial diplegia and similar neurophysiological pattern consistent with acute inflammatory demyelinating polyneuropathy, and recovered well. Furthermore, during the peak of ZIKV transmission, we observed a number of GBS cases higher than the calculated upper limit, emphasizing the fact that ZIKV is now a major trigger of GBS.

Keywords

Language
English (en-GB)

Creators
Simon, Olivier, Acket, Blandine, Forfait-Dubuc, Carole, Girault, Dominique, Gourinat, Ann-Claire, Millon, Pauline, Daures, Maguy, Vanhomwegen, Jessica, Billot, Segolene, Biron, Antoine, Hoinard, Damien, Descloux, Élodie, Guyon, David, Manuguerra, Jean-Claude, Laumond, Sylvie, Molko, Nicolas, Dupont-Rouzeyrol, Myrielle

Contributors
Centre hospitalier territorial Gaston-Bourret [Nouméa], CHU Toulouse [Toulouse], New Caledonia Health Department, Dengue et Arbovirose (URE-DA) ; Institut Pasteur de Nouvelle-Calédonie ; Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de Nouvelle-Calédonie ; Réseau International des Instituts Pasteur (RIIP), Cellule d'Intervention Biologique d'Urgence - Laboratory for Urgent Response to Biological Threats (CIBU) ; Institut Pasteur [Paris], Direction des affaires sanitaires et sociales de Nouvelle-Calédonie, Study partly funded by French Government’s Investissement d’Avenir Programme (Labex Integrative Biology of Emerging Infectious Diseases, IBEID, grant number ANR-10-LABX-62-IBEID), New Caledonia Government, Institut Pasteur in New Caledonia, Centre Hospitalier Territorial, New Caledonia and by the European Union’s Horizon 2020 Research and Innovation Programme under ZIKAlliance Grant Agreement no. 734548.

Sources
ISSN: 1355-0284, Journal of NeuroVirology, https://hal-riip.archives-ouvertes.fr/pasteur-01831514, Journal of NeuroVirology, Springer Verlag, 2018, 24 (3), pp.362 - 368. ⟨10.1007/s13365-018-0621-9⟩

Relation
info:eu-repo/semantics/altIdentifier/doi/10.1007/s13365-018-0621-9
info:eu-repo/semantics/altIdentifier/pmid/29594985

Coverage
Melanesia

Name of newspaper