Sujet
[SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.GEN]Life Sciences [q-bio]/Genetics

Domaines
Santé, Biologie, Sciences du vivant

Description

International audience BACKGROUND:GSTM1 and GSTT1 are involved in detoxification of xenobiotics, products of oxidative stress and in steroid hormones metabolism. We investigated whether GSTM1 and GSTT1 gene deletion was associated with DTC risk and explored interaction with non-genetic risk factors of DTC.METHODS:The study included 661 DTC cases and 736 controls from two case-control studies conducted in France and New Caledonia. Odds ratios (OR) and their confidence interval (CI) for DTC associated with GST genotypes, alcohol drinking, tobacco smoking, body mass index and hormonal factors were calculated using logistic regression models.RESULTS:Results are presented for Europeans and Melanesians combined, as no heterogeneity between groups was detected. We found that DTC risk increased with obesity and decrease with alcohol drinking. After stratification by gene deletion status, the OR for obesity was 5.75, (95%CI 2.25-14.7) among individuals with GSTT1 and GSTM1-deleted genotype, and 1.26, (95%CI 0.89-1.77) in carriers of both genes (p-interaction = 0.02). The OR for drinking ≥1 glass/week was 0.33 (95%CI 0.15-0.74) in GSTT1-null individuals while it was 1.01 (95%CI 0.67-1.52) in non-null carriers of the gene (p-interaction = 0.01). No interaction between GST genotypes and other non-genetic risk factors was detected.CONCLUSION:GSTM1 and GSTT1 genotypes may modulate the DTC risk associated with BMI and alcohol consumption.

Mots-clés

Langue
English (en-GB)

Auteurs
Tcheandjieu, Catherine, Cordina-Duverger, Emilie, Mulot, Claire, Baron-Dubourdieu, Dominique, Guizard, Anne-Valérie, Schvartz, Claire, Laurent-Puig, Pierre, Guénel, Pascal, Truong, Thérèse

Contributeurs
Centre de recherche en épidémiologie et santé des populations (CESP) ; Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)) ; École pratique des hautes études (EPHE) ; Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre hospitalier territorial Gaston-Bourret [Nouméa], Laboratoire d'Anatomie et Cytopathologie [CHT Gaston-Bourret] ; Laboratoire d'Anatomie et Cytopathologie, Registre Général des Tumeurs du Calvados ; CHU Caen ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC) ; Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE) ; Université de Caen Normandie (UNICAEN) ; Normandie Université (NU)-Normandie Université (NU)-CHU Caen ; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC) ; Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Jean Godinot [Reims] ; UNICANCER, Centre de Recherche des Cordeliers (CRC (UMR_S 872)) ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), The New Caledonia study was supported by grants from Fondation de France, Association pour la Recherche contre le Cancer (ARC), and Agence Française de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (ANSES, ex-AFSSET). The CATHY study was supported by grants from the ANSES, Ligue Nationale Contre le Cancer, Institut National du Cancer, Fondation de France, and the Epidemiology Committee of EDF. Catherine Tcheandjieu performed this work during her PhD studies with the support of Ecole des Hautes Etudes en Santé Publique (EHESP).

Sources
ISSN: 1932-6203, EISSN: 1932-6203, PLoS ONE, https://www.hal.inserm.fr/inserm-02468903, PLoS ONE, 2020, 15 (1), pp.e0228187. ⟨10.1371/journal.pone.0228187⟩

Relation
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0228187
info:eu-repo/semantics/altIdentifier/pmid/31999731

Couverture
Melanesia

Nom du journal